Cornforth reagent → 5,6-dihydro-6-methoxy-2H-pyran-3(4H)-one

HRID 2299109ノート

反応式

HRID 2299109 の反応式
C1C=C[NH+]=CC=1.C1C=C[NH+]=CC=1.[O-][Cr](O[Cr]([O-])(=O)=O)(=O)=O.[CH3:22][O:23][CH:24]1[O:29][CH2:28][CH:27]([OH:30])[CH2:26][CH2:25]1>C(Cl)Cl>[CH3:22][O:23][CH:24]1[O:29][CH2:28][C:27](=[O:30])[CH2:26][CH2:25]1

参加物

4

反応物 2

HCID 2724130Cornforth reagentHCID 122006502H-Pyran-3-ol, tetrahydro-6-methoxy-

生成物 1

HCID 1282735,6-dihydro-6-methoxy-2H-pyran-3(4H)-one収率 25.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

PDC (6.0 g, 28 mmol) was added to a solution of 6-methoxytetrahydro-2H-pyran-3-ol (2.0 g, 15 mmol) from step (394a) in methylene chloride (50 ml) at room temperature. The reaction was stirred overnight, filtered through silica gel and concentrated to give an oil. The product was distilled at 35° C. at 1000 mtorr pressure to give the 6-methoxydihydro-2H-pyran-3-(4H)-one (0.5 g, 25%) as an oil.

後処理

  1. filtrationfiltered through silica gel
  2. concentrationconcentrated
  3. customto give an oil
  4. distillationThe product was distilled at 35° C. at 1000 mtorr pressure

出典と根拠

ORDレコード
ord-f135f214a31248988c78dccee744c0c9
出典データセット
uspto-grants-2002_12
特許番号
US06495565B2

反応ノート

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