Sodium Hydroxide → 1-Methoxy-3-(3-methylbut-2-enylsulphanyl)benzene

HRID 22994

反応式

HRID 22994 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([SH:9])[CH:6]=[CH:7][CH:8]=1.[OH-].[Na+].[CH3:12][C:13](=[CH:15][CH2:16]Br)[CH3:14]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([S:9][CH2:16][CH:15]=[C:13]([CH3:14])[CH3:12])[CH:4]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 700922-Butene, 1-bromo-3-methyl-HCID 849893-Methoxybenzenethiol

生成物 1

HCID 225925921-Methoxy-3-(3-methylbut-2-enylsulphanyl)benzene収率 90.4%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒2 回

実験手順

50.45 g (360.0 mmol) of 3-methoxythiophenol, 360 ml of acetone and 14.40 g (360.0 mmol) of sodium hydroxide pellets are introduced into a one liter round-bottomed flask under a nitrogen atmosphere and the mixture is heated at reflux for three hours. A solution composed of 53.6 g (360.0 mmol) of 2-methyl-4-bromo-2-butene and of 60 ml of acetone is added dropwise. Reflux is maintained for sixteen hours and the reaction mixture is evaporated to dryness. Water is added, extraction is carried out with ethyl acetate, the organic phase is washed with water and then using a saturated sodium chloride solution, dried over magnesium sulphate and filtered, and the solvents are evaporated. The residue obtained is distilled under reduced pressure (5×10−2 bar/113° C.) to produce 67.81 g (90%) of the expected compound in the form or a pale-yellow oil.

後処理

  1. temperaturethe mixture is heated
  2. temperatureat reflux for three hours
  3. additionis added dropwise
  4. temperatureReflux
  5. temperatureis maintained for sixteen hours
  6. customthe reaction mixture is evaporated to dryness
  7. additionWater is added
  8. extractionextraction
  9. washthe organic phase is washed with water
  10. dry with materialdried over magnesium sulphate
  11. filtrationfiltered
  12. customthe solvents are evaporated
  13. customThe residue obtained
  14. distillationis distilled under reduced pressure (5×10−2 bar/113° C.)

出典と根拠

ORDレコード
ord-b12277d88d5544d0af86d992556ac845
出典データセット
uspto-grants-2005_02
特許番号
US06849658B2

関連ノート

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