Dimethyl Pentadecanedioate → Methyl 15-Hydroxypentadecanoate

HRID 2299574

反応式

HRID 2299574 の反応式
[C:1](OC)(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH3:18])=[O:16].[H][H]>[Cr].[Cu]>[OH:19][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH3:18])=[O:16]

参加物

4

反応物 2

HCID 11415366Dimethyl PentadecanedioateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 3496889Methyl 15-Hydroxypentadecanoate収率 35%

試薬・触媒・溶媒 1

HCID 9833946Chromium, compd. with copper (1:1)触媒

実験手順

150 g (499 mmol) of dimethyl 1,15-pentadecandioate and 750 mg (0.5% by weight per the diester) of a commercial copper-chromium catalyst (content of copper as copper oxides: 42% by weight) were added to an autoclave and subjected to hydrogenation reaction at the hydrogen pressure of 20.0 Mpa at 280° C. After 2 hours, methyl 15-hydroxypentadecanoate was obtained in 35% yield. The degree of the conversion was 67% the selectivity was 53%, and the yield was 35%.

出典と根拠

ORDレコード
ord-a9ac413624b5490cabdb2384afb428f9
出典データセット
uspto-grants-2002_12
特許番号
US06495706B2

関連ノート

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