Hydrochloric Acid → E-2-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxyimino]-2-(3-phenoxyphenyl)acetic acid

Sodium hydride (60% in oil, 107 mg) was added under a nitrogen atmosphere to a solution of methyl Z-2-hydroxyimino-2-(3-phenoxylphenyl)acetate (605 mg) and 4-(4-chloromethylphenoxymethyl)-5-methyl-2-phenyloxazole (700 mg) in N,N-dimethylformamide (10 ml) at room temperature and the mixture was stirred for 1 hour. After adding 1N HCl (5 ml), aqueous sodium bicarbonate was added, and then the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated aqueous sodium chloride, dried (MgSO4) and then concentrated. The residue was subjected to column chromatography on silica gel to obtain an oil from a fraction eluted with ethyl acetate-hexane (1:3, v/v). This oil was dissolved in tetrahydrofuran (10 ml)-methanol (5 ml), and 1N aqueous solution of sodium hydroxide (5 ml) was added and the mixture was stirred at 40° C. for 2 hours. 1N HCl (5.5 ml) was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated aqueous sodium chloride, dried (MgSO4) and then concentrated. The residual crystal was recrystallized from ethyl acetate-hexane to obtain Z-2-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxyimino]-2-(3-phenoxyphenyl)acetic acid (738 mg, yield 62%) as colorless crystals. m.p.: 173-174° C. (decomposition)

1. additionwas added
2. extractionthe mixture was extracted with ethyl acetate
3. washThe ethyl acetate layer was washed with saturated aqueous sodium chloride
4. dry with materialdried (MgSO4)
5. concentrationconcentrated
6. customto obtain an oil from a fraction
7. washeluted with ethyl acetate-hexane (1:3
8. dissolutionThis oil was dissolved in tetrahydrofuran (10 ml)-methanol (5 ml), and 1N aqueous solution of sodium hydroxide (5 ml)
9. additionwas added
10. stirringthe mixture was stirred at 40° C. for 2 hours
11. addition1N HCl (5.5 ml) was added to the reaction mixture
12. extractionthe mixture was extracted with ethyl acetate
13. washThe ethyl acetate layer was washed with saturated aqueous sodium chloride
14. dry with materialdried (MgSO4)
15. concentrationconcentrated
16. customThe residual crystal was recrystallized from ethyl acetate-hexane

ORDレコード

ord-c1b1d5760c3247ad9e16996d89fc3699

出典データセット

uspto-grants-2002_12

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06495581B1