4-Bromophenol → 4-Bromo-2-tert-butylphenol
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[CH3:9][C:10](=[CH2:12])[CH3:11]>>[C:10]([C:6]1[CH:7]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]=1[OH:8])([CH3:12])([CH3:11])[CH3:9]参加物
3
反応条件
- 温度
- 80 °C
実験手順
80.00 g (426.0 mmol) of 4-bromophenol and 8.00 g of Dowex 50WX8 sulphonic acid resin are mixed in a 250 ml three-necked flask. The mixture is heated to 80° C. and a stream of isobutylene is passed through for 30 hours. The reaction mixture is cooled and the residue is purified by passing through a silica column eluted with a mixture composed of 95% dichloromethane and of 5% heptane. 88.00 g (90%) of the expected compound are collected in the form of a yellow oil.
後処理
- customis passed through for 30 hours
- temperatureThe reaction mixture is cooled
- customthe residue is purified
- washeluted with a mixture
- custom88.00 g (90%) of the expected compound are collected in the form of a yellow oil
出典と根拠
- ORDレコード
- ord-e13260ce32574b5b9e5417084cc467b0
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06849658B2
反応ノート
読み込み中…