Hydrochloric Acid → 3-(Diethylsulfamoyl)benzoic acid

HRID 2300765

反応式

HRID 2300765 の反応式
Cl[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[CH2:14]([NH:16][CH2:17][CH3:18])[CH3:15].Cl>C(Cl)Cl>[CH2:14]([N:16]([CH2:17][CH3:18])[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3])[CH3:15]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 8021DiethylamineHCID 77641Benzoic acid, 3-(chlorosulfonyl)-

生成物 1

HCID 7945953-(Diethylsulfamoyl)benzoic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a solution of 3-(chlorosulfonyl)benzoic acid (1.02 g, 4.62 mmol) in CH2Cl2 (100 mL) at 0° C. was added diethylamine (2.4 mL, 23 mmol). The resulting mixture was stirred at 0° C. for 3 h then worked up by adding 2N aqueous HCl and extracting 3× with EtOAc. The combined organic was washed with brine then dried over MgSO4 and concentrated under reduced pressure. The residue was used without further purification.

後処理

  1. extractionextracting 3× with EtOAc
  2. washThe combined organic was washed with brine
  3. dry with materialthen dried over MgSO4
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was used without further purification

出典と根拠

ORDレコード
ord-90ed747076b34b5eba680df517cd9781
出典データセット
uspto-grants-2002_12
特許番号
US06498165B1

関連ノート

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