Thionyl Chloride → 4-Isothiocyanatobenzoyl chloride
反応式
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]=[C:11]=[S:12])=[CH:6][CH:5]=1)(O)=[O:2].S(Cl)([Cl:15])=O>>[N:10]([C:7]1[CH:8]=[CH:9][C:4]([C:1]([Cl:15])=[O:2])=[CH:5][CH:6]=1)=[C:11]=[S:12]参加物
3
実験手順
A mixture of 500 mg (2.79 mmol) of 4-carboxyphenylisothiocyanate and 5 ml of thionyl chloride was refluxed for 6 hours. The reaction mixture was concentrated at reduced pressure and the resulting tan solid was pumped at high vacuum overnight. The solid was triturated with a small amount of hexane and collected by suction filtration to yield 516 mg (93%) of product as an off-white solid.
後処理
- temperaturewas refluxed for 6 hours
- concentrationThe reaction mixture was concentrated at reduced pressure
- customwas pumped at high vacuum overnight
- customThe solid was triturated with a small amount of hexane
- filtrationcollected by suction filtration
出典と根拠
- ORDレコード
- ord-57092f1f27ce496cbeeb2375c53ed4c5
- 出典データセット
- uspto-grants-2009_07
- 特許番号
- US07566549B2
反応ノート
読み込み中…