Water → 6-iodo-1H-quinazoline-2,4-dione

HRID 2301065

反応式

HRID 2301065 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][C:3]=1[C:4](O)=[O:5].[NH2:12][C:13](N)=[O:14].O>CN1C(=O)CCC1>[I:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[NH:1][C:13](=[O:14])[NH:12][C:4]2=[O:5]

参加物

5

反応物 3

HCID 962WaterHCID 1176UreaHCID 72911Benzoic acid, 2-amino-5-iodo-

生成物 1

HCID 113806686-iodo-1H-quinazoline-2,4-dione収率 87.4%

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

反応条件

温度
160 °C

実験手順

A mixture of 2-amino-5-iodobenzoic acid (3.5 g) and urea (1.56 g) in NMP (15 ml) was heated at 160° C. for 6 hours then cooled. Water (200 ml) was added and the resultant precipitate was collected, washed with water and dried to give the title compound (3.35 g) as a solid. MS (CI): 289 (M+H)+.

後処理

  1. temperaturethen cooled
  2. customthe resultant precipitate was collected
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-55b39c4db08a431c9102d98fe03163de
出典データセット
uspto-grants-2002_12
特許番号
US06498275B1

関連ノート

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