Water → 6-iodo-1H-quinazoline-2,4-dione
反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][C:3]=1[C:4](O)=[O:5].[NH2:12][C:13](N)=[O:14].O>CN1C(=O)CCC1>[I:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[NH:1][C:13](=[O:14])[NH:12][C:4]2=[O:5]参加物
5
反応条件
- 温度
- 160 °C
実験手順
A mixture of 2-amino-5-iodobenzoic acid (3.5 g) and urea (1.56 g) in NMP (15 ml) was heated at 160° C. for 6 hours then cooled. Water (200 ml) was added and the resultant precipitate was collected, washed with water and dried to give the title compound (3.35 g) as a solid. MS (CI): 289 (M+H)+.
後処理
- temperaturethen cooled
- customthe resultant precipitate was collected
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-55b39c4db08a431c9102d98fe03163de
- 出典データセット
- uspto-grants-2002_12
- 特許番号
- US06498275B1
反応ノート
読み込み中…