Isopropylamine → HCID 18373477、化合物

反応式

[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[S:12](Cl)(=[O:14])=[O:13].[CH:16]([NH2:19])([CH3:18])[CH3:17].C(N(CC)CC)C>>[CH:16]([NH:19][S:12]([C:3]1[C:4]([Cl:11])=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=1[Cl:1])(=[O:14])=[O:13])([CH3:18])[CH3:17]

参加物

反応物 3

HCID 6363Isopropylamine

HCID 8471Triethylamine

HCID 234477722,6-Dichloro-3-nitrobenzene-1-sulfonyl chloride

生成物 1

HCID 18373477HCID 18373477、化合物収率 81%

実験手順

Following the general procedure for sulfonamide formation outlined in example 15, 2,6-dichloro-3-nitrobenzenesulfonyl chloride (1.5 g, 5.17 mmol), isopropylamine (0.44 m, 5.17 mmol) and triethylamine (1.08 mL, 7.76 mmol) were reacted to form the desired product (1.3 g, 81 %). EI-MS m/z 312 (M-H)−.