Water → HCID 18373430、化合物

反応式

[CH:1]([NH:4][S:5]([C:8]1[C:13]([Cl:14])=[CH:12][CH:11]=[C:10]([N+:15]([O-:17])=[O:16])[C:9]=1Cl)(=[O:7])=[O:6])([CH3:3])[CH3:2].[H-].[Na+].[OH2:21]>>[CH:1]([NH:4][S:5]([C:8]1[C:13]([Cl:14])=[CH:12][CH:11]=[C:10]([N+:15]([O-:17])=[O:16])[C:9]=1[OH:21])(=[O:7])=[O:6])([CH3:3])[CH3:2]

参加物

反応物 3

HCID 962Water

HCID 24758Sodium hydride

HCID 18373477HCID 18373477、化合物

生成物 1

HCID 18373430HCID 18373430、化合物収率 57.2%

実験手順

Following the general hydrolysis procedure outlined in example 15, N-isopropyl-2,6-dichloro-3-nitrobenzenesulfonamide (1.3 g, 4.15 mmol), NaH (60%, 500 mg, 12.45 mmol) and water (89 mg, 4.98 mmol) were reacted to form the desired product (0.7 g, 57%). EI- MS m/z 293.5 (M-H)−.