ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Cesium carbonate → Methyl [1-benzhydryl-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-chloro-1H-indol-3-yl](oxo)acetate

HRID 2301669
ノート
印刷プレビュー

反応式

HRID 2301669 の反応式
[Si:1]([O:8][CH2:9][C:10]1[NH:11][C:12]2[C:17]([C:18]=1[C:19](=[O:24])[C:20]([O:22][CH3:23])=[O:21])=[CH:16][C:15]([Cl:25])=[CH:14][CH:13]=2)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[CH:26](Br)([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.C([O-])([O-])=O.[Cs+].[Cs+]>C(#N)C>[CH:26]([N:11]1[C:12]2[C:17](=[CH:16][C:15]([Cl:25])=[CH:14][CH:13]=2)[C:18]([C:19](=[O:24])[C:20]([O:22][CH3:23])=[O:21])=[C:10]1[CH2:9][O:8][Si:1]([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2])([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 10796Cesium carbonateHCID 236603BromodiphenylmethaneHCID 90772388Methyl [2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-chloro-1h-indol-3-yl](oxo)acetate

生成物 1

HCID 86758767Methyl [1-benzhydryl-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-chloro-1H-indol-3-yl](oxo)acetate収率 60%

試薬・触媒・溶媒 1

HCID 6342
Acetonitrile
溶媒

実験手順

Methyl [2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-chloro-1H-indol-3-yl](oxo)acetate (1 eq), Ph2CHBr (2 eq) and Cs2CO3 (1.5 eq) were mixed in dry acetonitrile (0.13M) under N2. The mixture was heated with stirring to reflux for 3 hrs. The reaction mixture was cooled to rt and filtered and solvent was removed. Resulting residue was purified using a column with 1:4Hexane/CH2Cl2 as eluent to give methyl [1-benzhydryl-2-({[tert-butyl(dimethyl)silyl]oxy }methyl)-5-chloro-1H-indol-3-yl](oxo)acetate (yellow-brown solid) in 60% yield.

後処理

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 3 hrs
  3. filtrationfiltered
  4. customsolvent was removed
  5. customResulting residue was purified

出典と根拠

ORDレコード
ord-5d35a49db6e440a3a8f38399b8580ae9
出典データセット
uspto-grants-2002_12
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06500853B1

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート