4-Iodoaniline → HCID 66911973、化合物

反応式

[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.Cl[C:10]1[N:15]=[C:14]([O:16][CH3:17])[CH:13]=[C:12]([O:18][CH3:19])[N:11]=1.[H-].[Na+]>>[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:10]2[N:15]=[C:14]([O:16][CH3:17])[CH:13]=[C:12]([O:18][CH3:19])[N:11]=2)=[CH:4][CH:3]=1

参加物

反応物 3

HCID 108934-Iodoaniline

HCID 24758Sodium hydride

HCID 51523232-Chloro-4,6-dimethoxypyrimidine

生成物 1

HCID 66911973HCID 66911973、化合物収率 39.3%

実験手順

In the same manner as in Reference Example 24-(1), 4-iodoaniline (220 mg) and 2-chloro-4,6-dimethoxypyrimidine (200 mg) were reacted in the presence of sodium hydride to obtain N-(4-iodophenyl)-4,6-dimethoxypyrimidin-2-amine (141 mg). (2) In the same manner as in Reference Example 24-(2), sodium hydride (16 mg), N-(4-iodophenyl)-4,6-dimethoxypyrimidin-2-amine (140 mg) and methyl iodide (0.024 ml) were reacted to obtain N-(4-iodophenyl)-4,6-dimethoxy-N-methylpyrimidin-2-amine (118 mg).

出典と根拠

ORDレコード: ord-0244de1553dc4b859bf8a35a37af598d
出典データセット: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07566724B2

反応ノート

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