Sodium Hydroxide → 4-(3-Methylanilino)-2-[(2-ureidoethyl)amino]pyrimidine-5-carboxamide

HRID 2303312ノート

反応式

HRID 2303312 の反応式
[O-:1][C:2]#[N:3].[K+].Cl.O1CCOCC1.[NH2:12][CH2:13][CH2:14][NH:15][C:16]1[N:21]=[C:20]([NH:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([CH3:29])[CH:24]=2)[C:19]([C:30]([NH2:32])=[O:31])=[CH:18][N:17]=1.[OH-].[Na+]>O1CCOCC1.O>[CH3:29][C:25]1[CH:24]=[C:23]([CH:28]=[CH:27][CH:26]=1)[NH:22][C:20]1[C:19]([C:30]([NH2:32])=[O:31])=[CH:18][N:17]=[C:16]([NH:15][CH2:14][CH2:13][NH:12][C:2]([NH2:3])=[O:1])[N:21]=1

参加物

7

反応物 4

HCID 14798Sodium HydroxideHCID 98173492-(2-Aminoethylamino)-4-(m-tolylamino)pyrimidine-5-carboxamideHCID 11378442Potassium cyanateHCID 204431481,4-Dioxane hydrochloride

生成物 1

HCID 184608294-(3-Methylanilino)-2-[(2-ureidoethyl)amino]pyrimidine-5-carboxamide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

A 147 mg portion of potassium cyanate and 450 μl of 4 M hydrochloric acid-dioxane solution were added to a mixture of 312 mg of 2-(2-aminoethylamino)-4-(3-methylanilino)pyrimidine-5-carboxamide and 3 ml of water and 3 ml of 1,4-dioxane, followed by stirring at room temperature for 1 day. The reaction mixture was alkalified by adding 1 M sodium hydroxide aqueous solution, and the thus formed precipitate was collected by filtration. The filtered material was washed by stirring it in methanol while heating and then collected by filtration to obtain 212 mg of 4-(3-methylanilino)-2-[(2-ureidoethyl)amino]pyrimidine-5-carboxamide (colorless solid).

後処理

  1. filtrationthe thus formed precipitate was collected by filtration
  2. washThe filtered material was washed
  3. stirringby stirring it in methanol
  4. temperaturewhile heating
  5. filtrationcollected by filtration

出典と根拠

ORDレコード
ord-ba3eff2c6e214304bc183c3df6a17171
出典データセット
uspto-grants-2002_08
特許番号
US06432963B1

反応ノート

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