Sodium borohydride → HCID 11047852、化合物

HRID 2304559ノート

反応式

HRID 2304559 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][C:18]=1[F:19])[N:15]=[C:14]([I:20])[C:13]([CH:21]=[O:22])=[CH:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+]>CO>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][C:18]=1[F:19])[N:15]=[C:14]([I:20])[C:13]([CH2:21][OH:22])=[CH:12]2)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 22987158HCID 22987158、化合物

生成物 1

HCID 11047852HCID 11047852、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A suspension of 6-benzyloxy-7-fluoro-2-iodo-3-quinolinecarbaldehyde (obtained according to 1.e, 13 g, 32 mmol) in methanol (100 ml) is treated with sodium borohydride (1.85 g, 48 mmol). After 1 hour of reaction, the reaction medium is concentrated under reduced pressure then taken up with water, filtered, washed with water and ethanol in order to produce, after drying under reduced pressure, 10 g (76%) of a white solid, m.p. 188° C.

後処理

  1. customAfter 1 hour of reaction
  2. concentrationthe reaction medium is concentrated under reduced pressure
  3. filtrationfiltered
  4. washwashed with water and ethanol in order
  5. customto produce
  6. dry with materialafter drying under reduced pressure, 10 g (76%) of a white solid, m.p. 188° C.

出典と根拠

ORDレコード
ord-ea7d5449aba440ba9a6ce7d826699629
出典データセット
uspto-grants-2002_08
特許番号
US06436951B1

反応ノート

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