Hydrogen Bromide → 5-Bromomethyl-2-pyridone
反応式
O[CH2:2][C:3]1[CH:4]=[CH:5][C:6](=[O:9])[NH:7][CH:8]=1.[BrH:10]>>[Br:10][CH2:2][C:3]1[CH:4]=[CH:5][C:6](=[O:9])[NH:7][CH:8]=1参加物
3
反応条件
- 温度
- 100 °C
実験手順
To 5-hydroxymethyl-2-pyridone (114.9 mg, 0.9 mmol) was added 3.0 ml of 48% hydrobromic acid. The mixture was heated at 100° C. for 20 minutes. The excess hydrobromic acid was then evaporated in vacuo to give the corresponding 5-bromomethyl-2-pyridone. This compound was used without purification. HRMS: m/e, M+found; 186.9626, 7.4% Calc. for C6H6BrNO: 186.9633, −3.9 ppm.
後処理
- customThe excess hydrobromic acid was then evaporated in vacuo
出典と根拠
- ORDレコード
- ord-82cdd48aea6b476fa372d24e755202a3
- 出典データセット
- uspto-grants-2002_08
- 特許番号
- US06436972B1
反応ノート
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