Ammonia → 4-(Trifluoromethyl)cyclohexane-1-carboxamide

温度

0 °C

At 0° C. 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (2.90 g, 15.29 mmol) was added to a solution of 4-(trifluoromethyl)cyclohexanecarboxylic acid (3.0 g, 15.29 mmol) and 1-hydroxybenzotriazole (2.1 g, 15.29 mmol) in DMF (10 ml) and DCM (10 ml). The reaction mixture was stirred for 20 min at 0° C. A saturated solution of ammonia in methanol (17 ml) was added. The reaction mixture was stirred for 16 hours, while it was warming up to room temperature. It was diluted with ethyl acetate (100 ml) and washed with a 10% aqueous solution of sodium hydrogen sulphate (100 ml). The aqueous phase was extracted with ethyl acetate (2×80 ml). The combined organic layers were washed with a saturated aqueous solution of sodium hydrogen carbonate (100 ml) and dried over magnesium sulphate. The solvent was removed in vacuo. The crude product was purified by flash chromatography on silica, using DCM/methanol/25% aqueous ammonia (100:10:1) as eluent, to give 1.99 g of 4-trifluoromethylcyclohexanecarboxylic acid amide.

1. customAt 0° C
2. stirringThe reaction mixture was stirred for 16 hours, while it
3. temperaturewas warming up to room temperature
4. washwashed with a 10% aqueous solution of sodium hydrogen sulphate (100 ml)
5. extractionThe aqueous phase was extracted with ethyl acetate (2×80 ml)
6. washThe combined organic layers were washed with a saturated aqueous solution of sodium hydrogen carbonate (100 ml)
7. dry with materialdried over magnesium sulphate
8. customThe solvent was removed in vacuo
9. customThe crude product was purified by flash chromatography on silica

ORDレコード

ord-63f5df730bd24654ac07ce397f7be092

出典データセット

uspto-grants-2002_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06437147B1