Isobutyl pyruvate → N-(2-methylquinolin-6-yl)alanine Iso-butyl Ester
反応式
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[CH:6]=[CH:5]2.[C:13]([O:18][CH2:19][CH:20]([CH3:22])[CH3:21])(=[O:17])[C:14]([CH3:16])=O>>[CH2:19]([O:18][C:13](=[O:17])[C@H:14]([CH3:16])[NH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[CH:6]=[CH:5]2)[CH:20]([CH3:22])[CH3:21]参加物
3
実験手順
Following General Procedure AA above and using 6-amino-2-methylquinoline (Lancaster) and iso-butyl pyruvate (prepared by following General Procedure AO above), the title compound was prepared. The reaction was monitored by silica gel tlc (Rf=0.44 in 50% EtOAc/hexanes). Purification was by flash chromatography (silica gel using 50% EtOAc/hexanes as the eluant).
後処理
- customPurification
出典と根拠
- ORDレコード
- ord-e4defc8176564c78905f4f164eeb6e1d
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06849650B2
反応ノート
読み込み中…