3-(4-Benzyloxy-phenyl)-2-ethoxy-propionic acid methyl ester → 2-Ethoxy-3-(4-hydroxy-phenyl)-propionic acid methyl ester

HRID 2305318ノート

反応式

HRID 2305318 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([O:21][CH2:22][CH3:23])[C:17]([O:19][CH3:20])=[O:18])=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>C(OCC)(=O)C.[Pd]>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH:16]([O:21][CH2:22][CH3:23])[C:17]([O:19][CH3:20])=[O:18])=[CH:13][CH:14]=1

参加物

5

反応物 2

HCID 219309623-(4-Benzyloxy-phenyl)-2-ethoxy-propionic acid methyl esterHCID 178418361HCID 178418361、化合物

生成物 1

HCID 149239942-Ethoxy-3-(4-hydroxy-phenyl)-propionic acid methyl ester収率 84%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

A suspension of methyl 3-[4-benzyloxyphenyl)-2-ethoxypropanoate (3.7 g, 11.78 mmol; preparation 2) and 10% Pd-C (0.37 g) in ethyl acetate (50 mL) was stirred at 25° C. under 60 psi hydrogen pressure for 24 h. The catalyst was filtered and the solvent was evaporated under reduced pressure. The residue was chromatographed over silica gel using a mixture of ethyl acetate and pet. ether (2:8) as an eluent to afford the title compound (2.2 g, 84%) as an oil.

後処理

  1. filtrationThe catalyst was filtered
  2. customthe solvent was evaporated under reduced pressure
  3. customThe residue was chromatographed over silica gel using
  4. additiona mixture of ethyl acetate and pet. ether (2:8) as an eluent

出典と根拠

ORDレコード
ord-880a37afa876453aa2d6230c274b3e7f
出典データセット
uspto-grants-2002_08
特許番号
US06440961B1

反応ノート

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