Methyl 3-methyl-4-(2-methoxy-5-nitrophenoxy)butyrate → Methyl 3-methyl-4-(2-methoxy-5-aminophenoxy)butyrate

HRID 2305630ノート

反応式

HRID 2305630 の反応式
[CH3:1][CH:2]([CH2:8][O:9][C:10]1[CH:15]=[C:14]([N+:16]([O-])=O)[CH:13]=[CH:12][C:11]=1[O:19][CH3:20])[CH2:3][C:4]([O:6][CH3:7])=[O:5].[H][H]>CO.[Pd]>[CH3:1][CH:2]([CH2:8][O:9][C:10]1[CH:15]=[C:14]([NH2:16])[CH:13]=[CH:12][C:11]=1[O:19][CH3:20])[CH2:3][C:4]([O:6][CH3:7])=[O:5]

参加物

5

反応物 2

HCID 18433387Methyl 3-methyl-4-(2-methoxy-5-nitrophenoxy)butyrateHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 11322746Methyl 3-methyl-4-(2-methoxy-5-aminophenoxy)butyrate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

At ambient temperature a rapidly stirred solution of methyl 3-methyl-4-(2-methoxy-5-nitrophenoxy)butyrate(400 mg) in methanol (20 mL) containing 10% palladium on carbon (40 mg) was exposed to an atmosphere of hydrogen. When uptake of hydrogen had ceased the solution was filtered and the filter cake washed with methanol. The combined filtrates were evaporated to dryness under reduced pressure, to give methyl 3-methyl-4-(2-methoxy-5-aminophenoxy)butyrate as an oil. (317 mg) m/Z 254(M+H).

後処理

  1. filtrationwas filtered
  2. washthe filter cake washed with methanol
  3. customThe combined filtrates were evaporated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-3f77f4683d644ee1a3028b3cc4762386
出典データセット
uspto-grants-2002_08
特許番号
US06441012B1

反応ノート

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