Water → 2-Methoxy-8-nitroquinoline
反応式
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[NH:12][C:11](=[O:14])[CH:10]=[CH:9]2)([O-:3])=[O:2].[C:15]([O-])([O-])=O.[Cs+].[Cs+].IC.O>CN(C=O)C>[CH3:15][O:14][C:11]1[CH:10]=[CH:9][C:8]2[C:13](=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=[CH:6][CH:7]=2)[N:12]=1参加物
6
実験手順
To a stirred solution of 1,2-dihydro-8-nitroquinolin-2-one, as described above in Step C, (2.55 g, 13.41 mmol) in DMF (80 mL) were added Cs2CO3 (13.11 g, 40.23 mmol) and iodomethane (1.37 mL, 14.75 mmol) and the mixture was stirred vigorously for 2.5 hours. The reaction mixture was poured into water at 0° C. and the solid was isolated by filtration. The resulting solid was dried in vacuo, to yield the above-titled compound.
後処理
- customthe solid was isolated by filtration
- customThe resulting solid was dried in vacuo
出典と根拠
- ORDレコード
- ord-073aa1f48b334f07b5673d77feb0e0e4
- 出典データセット
- uspto-grants-2002_08
- 特許番号
- US06441017B1
反応ノート
読み込み中…