Sodium Hydroxide → 3-Methylbenzo[d]isoxazole-6-carboxylic acid

HRID 2306662ノート

反応式

HRID 2306662 の反応式
[CH3:1][C:2]1[C:6]2[CH:7]=[CH:8][C:9]([C:11]([O:13]C)=[O:12])=[CH:10][C:5]=2[O:4][N:3]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[C:6]2[CH:7]=[CH:8][C:9]([C:11]([OH:13])=[O:12])=[CH:10][C:5]=2[O:4][N:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 22610095HCID 22610095、化合物

生成物 1

HCID 226100463-Methylbenzo[d]isoxazole-6-carboxylic acid収率 92%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl 3-methyl-1,2-benzisoxazole-6-carboxylate (170 mg, 0.89 mmole) is dissolved in 6 ml MeOH under nitrogen. The solution is treated with 2N aqueous NaOH (1 ml, 2 mmole) and the mixture is stirred 4 h at rt. The volatiles are removed in vacuo and the residue is dissolved in 4 ml water. The pH of the solution is adjusted to 3 with 10% aqueous HCl, the white precipitate is collected, is washed with water, and is dried to give 144 mg (92%) of 3-methyl-1,2-benzisoxazole-6-carboxylic acid as a white solid. MS m/z (ESI): 176.2 (M−H)−.

後処理

  1. customThe volatiles are removed in vacuo
  2. dissolutionthe residue is dissolved in 4 ml water
  3. customthe white precipitate is collected
  4. washis washed with water
  5. customis dried

出典と根拠

ORDレコード
ord-b5edccec4cfc443ea80447c37bfbc9dc
出典データセット
uspto-grants-2004_12
特許番号
US06828330B2

反応ノート

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