Diethyl (1-cyanoethyl)phosphonate → 2-(3,3,5,5-Tetramethylcyclohexylidene)propionitrile

HRID 2307085

反応式

HRID 2307085 の反応式
[CH3:1][C:2]1([CH3:13])[CH2:7][C:6]([CH3:9])([CH3:8])[CH2:5][C:4](=[CH:10][C:11]#[N:12])[CH2:3]1.[C:14](C(P(=O)(OCC)OCC)C)#N>>[CH3:1][C:2]1([CH3:13])[CH2:7][C:6]([CH3:8])([CH3:9])[CH2:5][C:4](=[C:10]([CH3:14])[C:11]#[N:12])[CH2:3]1

参加物

3

反応物 2

HCID 282103Diethyl (1-cyanoethyl)phosphonateHCID 226301503,3,5,5-Tetramethylcyclohexylideneacetonitrile

生成物 1

HCID 226301582-(3,3,5,5-Tetramethylcyclohexylidene)propionitrile収率 41%

実験手順

Prepared according to the procedure for compound 20 (Example 10, a) using diethyl (1-cyanoethyl)phosphonate. Nitrile 21 obtained as a colorless oil with 41% yield. 1H-NMR: (CDCl3, TMS): 0.96 and 1.00 (total 12H, both s, c-Hex-3,5-CH3); 1.34 (2H, s, c-Hex-4-CH2); 1.91 (3H, s, propionitrile-3-CH3); 2.04 and 2.28 ppm (total 4H, both s, c-Hex-2,6-CH2).

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-21238243ee2d4cc49273a5b3675f7004
出典データセット
uspto-grants-2004_12
特許番号
US06828462B2

関連ノート

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