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Triethylamine → 1-Nicotinoyl-3-phenyl-2-pyrazoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3-Pyridinecarbonyl chloride, hydrochloride (1:1) | HCID 88438 | — |
| 反応物 | 3-Phenyl-4,5-dihydro-1H-pyrazole | HCID 589745 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 1-Nicotinoyl-3-phenyl-2-pyrazoline | HCID 9819657 | 74.2% |
反応手順
3-Phenyl-2-pyrazoline (2.9 g) synthesized in Reference Example 2 was dissolved in chloroform (20 ml). Thereto were added nicotinic acid chloride hydrochloride (4 g) and triethylamine (6 ml) with ice-cooling. Stirring was conducted for 30 minutes at room temperature. The reaction mixture was washed with water and concentrated under vacuum. The residue was purified by silica gel column chromatography (methanol:chloroform=1/100) to obtain 3.7 g of a title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06831083B2 |
| 出典データセット | uspto-grants-2004_12 |
| ORD ID | ord-6893ebef7bf741d3bf85b5185d3d46de |
| 出典メモ | uspto-grants-2004_12 |