反应详情

3-Phenyl-2-pyrazoline (2.9 g) synthesized in Reference Example 2 was dissolved in chloroform (20 ml). Thereto were added nicotinic acid chloride hydrochloride (4 g) and triethylamine (6 ml) with ice-cooling. Stirring was conducted for 30 minutes at room temperature. The reaction mixture was washed with water and concentrated under vacuum. The residue was purified by silica gel column chromatography (methanol:chloroform=1/100) to obtain 3.7 g of a title compound.

1. temperaturecooling
2. washThe reaction mixture was washed with water
3. concentrationconcentrated under vacuum
4. customThe residue was purified by silica gel column chromatography (methanol:chloroform=1/100)