HCID 22176515、化合物 → HCID 22176470、化合物
反応式
[Br:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[C:4]([CH2:11][CH3:12])[N+:3]=1[O-]>C(O)(=O)C.[Fe]>[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[C:4]([CH2:11][CH3:12])[N:3]=1参加物
4
反応条件
- 温度
- 100 °C
実験手順
A solution of 2-bromo-6-ethyl-4-nitro-pyridine 1-oxide (example 5b) (15.9 g, 69 mmol) in acetic acid (310 ml) was treated with powdered iron (25.8 g, 462 mmol). The mixture was slowly heated to 100° C. and kept for 1 hr at this temperature. Then the reaction mixture was cooled to rt and filtered. After evaporation of the solvent the residue was crystallized to yield the title compound as a beige material (88%). Mp. 75-77° C. (pentane), MS: m/e=200 (M+).
後処理
- temperatureThen the reaction mixture was cooled to rt
- filtrationfiltered
- customAfter evaporation of the solvent the residue
- customwas crystallized
出典と根拠
- ORDレコード
- ord-a7269623d10b431a89cebff5584cc744
- 出典データセット
- uspto-grants-2004_12
- 特許番号
- US06831087B2
反応ノート
読み込み中…