4-Phenylbutyric Acid → N-(4phenylbutanoyl)-L-alanine iso-butyl ester

HRID 23073

反応式

HRID 23073 の反応式
[C:1]1([CH2:7][CH2:8][CH2:9][C:10]([OH:12])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH2:14]([O:18][C:19](=[O:23])[C@H:20]([CH3:22])[NH2:21])[CH:15]([CH3:17])[CH3:16]>>[CH2:14]([O:18][C:19](=[O:23])[C@H:20]([CH3:22])[NH:21][C:10](=[O:12])[CH2:9][CH2:8][CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH:15]([CH3:17])[CH3:16]

参加物

3

反応物 2

HCID 47754-Phenylbutyric AcidHCID 865849812-Methylpropyl (2S)-2-aminopropanoate hydrochloride

生成物 1

HCID 15481769N-(4phenylbutanoyl)-L-alanine iso-butyl ester

実験手順

Following General Procedure BB and using 4-phenylbutanoic acid (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as an oil. The reaction was monitored by tic on silica gel and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.

後処理

  1. customtic on silica gel and purification
  2. extractionwas by extraction with Et2O

出典と根拠

ORDレコード
ord-fb7dd00c26ef4e8ab059239037eb944b
出典データセット
uspto-grants-2005_02
特許番号
US06849650B2

関連ノート

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