2,2,2-Trifluoro-1-(3-nitrophenyl)ethanone oxime → 1-(3-Aminophenyl)-2,2,2-trifluoroethanone oxime
反応式
[F:1][C:2]([F:16])([F:15])[C:3]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-])=O)[CH:7]=1)=[N:4][OH:5]>C(O)C.[Pt]>[NH2:12][C:8]1[CH:7]=[C:6]([C:3](=[N:4][OH:5])[C:2]([F:16])([F:15])[F:1])[CH:11]=[CH:10][CH:9]=1参加物
4
実験手順
A mixture of 2,2,2-trifluoro-1-(3-nitrophenyl)ethanone oxime (2.34 g) and 5% Pt(S)/C (2340 mg) in ethanol (530 mL) was hydrogenated at 50 psi for 2 hours. The crude reaction mixture was filtered, and the filtrate was concentrated in vacuo to give the title compound (2 g) as an oil which was used in the next step without purification.
後処理
- customThe crude reaction mixture
- filtrationwas filtered
- concentrationthe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-781754cffd2045d4b7fb88111374373f
- 出典データセット
- uspto-grants-2004_12
- 特許番号
- US06831080B2
反応ノート
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