1-(Cyclopentylsulfonyl)-4-nitrobenzene → 4-(Cyclopentanesulfonyl)aniline
反応式
[CH:1]1([S:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=2)(=[O:8])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1>C(O)(=O)C.[Pd].CO>[CH:1]1([S:6]([C:9]2[CH:10]=[CH:11][C:12]([NH2:15])=[CH:13][CH:14]=2)(=[O:8])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1参加物
5
実験手順
Intermediate 2 (13.1 g) was dissolved in acetic acid (150 ml) and hydrogenated over palladium on activated carbon (1.6 g) with stirring overnight. The mixture was filtered through Celite filter aid, and the filtrate was evaporated to give a yellow/green oil. The oil was taken up in methanol and an insoluble precipitate filtered off; the filtrate was evaporated in vacuo to give a yellow solid. Trituration with ether and filtration gave the title compound as a pale yellow solid (8.1 g).
後処理
- filtrationThe mixture was filtered through Celite
- filtrationfilter aid
- customthe filtrate was evaporated
- customto give a yellow/green oil
- filtrationan insoluble precipitate filtered off
- customthe filtrate was evaporated in vacuo
- customto give a yellow solid
- filtrationTrituration with ether and filtration
出典と根拠
- ORDレコード
- ord-c1252f81086244a2aaf7124be1d79e28
- 出典データセット
- uspto-grants-2009_07
- 特許番号
- US07566786B2
反応ノート
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