m-Chloroperbenzoic acid → m-Chloroperbenzoic acid

HRID 2308383

反応式

HRID 2308383 の反応式
[Cl:1][CH:2]([Cl:18])[S:3]([C:5]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][C:10]([F:16])=[CH:11][CH:12]=2)[N:7]([CH3:17])[CH:6]=1)=[O:4].ClC(Cl)SC1C(=O)C2C(=CC(F)=CC=2)N(C)C=1.[Cl:36][C:37]1[CH:42]=[CH:41][CH:40]=[C:39]([C:43]([O:45][OH:46])=[O:44])[CH:38]=1>ClCCl>[Cl:1][CH2:2][S:3][C:5]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][C:10]([F:16])=[CH:11][CH:12]=2)[N:7]([CH3:17])[CH:6]=1.[Cl:36][C:37]1[CH:42]=[CH:41][CH:40]=[C:39]([C:43]([O:45][OH:46])=[O:44])[CH:38]=1.[Cl:18][CH:2]([Cl:1])[S:3]([C:5]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][C:10]([F:16])=[CH:11][CH:12]=2)[N:7]([CH3:17])[CH:6]=1)=[O:4]

参加物

7

反応物 3

HCID 70297m-Chloroperbenzoic acidHCID 103805373-Dichloromethylsulfinyl-7-fluoro-1-methyl-4-quinoloneHCID 113237793-Dichloromethylthio-7-fluoro-1-methyl-4-quinolone

生成物 3

HCID 70297m-Chloroperbenzoic acidHCID 103805373-Dichloromethylsulfinyl-7-fluoro-1-methyl-4-quinoloneHCID 104452083-Chloromethylthio-7-fluoro-1-methyl-4-quinolone

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

In another embodiment, the present invention contemplates a method for the synthesis so of 3-dichloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone (dichloroflosequinan) comprising: a) providing, i) 3-dichloromethylthio-7-fluoro-1-methyl-4-quinolone, ii) dichloromethane (DCM), and iii) m-chloroperbenzoic acid (MCPBA); and b) reacting, i) 3-chloromethylthio-7-fluoro-1-methyl-4-quinolone, ii) dichloromethane (DCM), and iii) m-chloroperbenzoic acid (“MCPBA”) under conditions such that 3-dichloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone is produced.

後処理

  1. customa) providing

出典と根拠

ORDレコード
ord-140201a26f894c01ab5126a1cf97b9c4
出典データセット
uspto-grants-2004_12
特許番号
US06835836B2

関連ノート

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