3-Methoxyaniline → 6-Iodo-4-{[3-(methyloxy)phenyl]amino}-3-quinolinecarboxamide hydrochloride

HRID 230839ノート

反応式

HRID 230839 の反応式
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([I:12])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:13]([NH2:15])=[O:14].[CH3:16][O:17][C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][CH:24]=1)[NH2:21]>C(O)C>[ClH:1].[I:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][C:3]([C:13]([NH2:15])=[O:14])=[C:2]2[NH:21][C:20]1[CH:22]=[CH:23][CH:24]=[C:18]([O:17][CH3:16])[CH:19]=1

参加物

4

反応物 2

HCID 108243-MethoxyanilineHCID 577632714-Chloro-6-iodoquinoline-3-carboxamide

生成物 1

HCID 674246056-Iodo-4-{[3-(methyloxy)phenyl]amino}-3-quinolinecarboxamide hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Intermediate 13 (5.0 g) was dissolved in ethanol (60 ml), 3-methoxyaniline (3.37 ml) (available from Aldrich) was added, and the mixture was heated under reflux for 2.5 h. The resulting precipitate was filtered off and washed with ether to give the title compound.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 2.5 h
  3. filtrationThe resulting precipitate was filtered off
  4. washwashed with ether

出典と根拠

ORDレコード
ord-37f88493502743c4a8b42cda0fa94fe9
出典データセット
uspto-grants-2009_07
特許番号
US07566786B2

反応ノート

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