N-(5-Chloro-3-methylidene-2,3-dihydro-1-benzofuran-4-yl)-2,2,2-trifluoroacetamide → 2,2,2-Trifluoro-N-(3-methyl-2,3-dihydro-1-benzofuran-4-yl)acetamide

HRID 230848

反応式

HRID 230848 の反応式
Cl[C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][C:7](=[CH2:10])[C:6]=2[C:11]=1[NH:12][C:13](=[O:18])[C:14]([F:17])([F:16])[F:15]>C(O)C.[Pd]>[F:17][C:14]([F:15])([F:16])[C:13]([NH:12][C:11]1[C:6]2[CH:7]([CH3:10])[CH2:8][O:9][C:5]=2[CH:4]=[CH:3][CH:2]=1)=[O:18]

参加物

4

反応物 1

HCID 57763270N-(5-Chloro-3-methylidene-2,3-dihydro-1-benzofuran-4-yl)-2,2,2-trifluoroacetamide

生成物 1

HCID 577632852,2,2-Trifluoro-N-(3-methyl-2,3-dihydro-1-benzofuran-4-yl)acetamide収率 104.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of Intermediate 23 (0.10 g) in ethanol (20 ml) was added to 10% palladium on carbon (0.20 g) and the mixture stirred under an atmosphere of hydrogen for 20 h. The mixture was filtered through ‘hyflo’ filter aid, washed with ethanol and the solvent removed in vacuo to give the title compound as a white solid (0.092 g).

後処理

  1. filtrationThe mixture was filtered through ‘hyflo’
  2. filtrationfilter aid
  3. washwashed with ethanol
  4. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-07a50bda887847c5a08ffd5d164601dd
出典データセット
uspto-grants-2009_07
特許番号
US07566786B2

関連ノート

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