Tetrahydrofuran → (4-Methoxy-7-phenyl-benzothiazol-2-yl)-thiourea

反応式

C([NH:9][C:10]([NH:12][C:13]1[S:14][C:15]2[C:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:20][CH:19]=[C:18]([O:28][CH3:29])[C:16]=2[N:17]=1)=[S:11])(=O)C1C=CC=CC=1.C1COCC1.C[O-].[Na+]>CO>[CH3:29][O:28][C:18]1[C:16]2[N:17]=[C:13]([NH:12][C:10]([NH2:9])=[S:11])[S:14][C:15]=2[C:21]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:20][CH:19]=1

参加物

実験手順

To a solution of 1-benzoyl-3-(4-methoxy-7-phenyl-benzothiazol-2-yl)-thiourea (1.3 g, 3.1 mmol) in methanol (20 ml)/THF (40 ml) was added NaOMe (250 mg, 4.6 mmol) and the mixture stirrd for 72 h at r.t. After evaporation of the solvents water (100 ml) was added with stirring followed by aceticacid (1 ml) which caused a solid to precipitate. This solid was collected and on a glass sinter, washed with water (100 ml), followed by EtOAc (30 ml) then finally cyclohexane (30 ml). After drying the title compound was obtained as a white solid (850 mg, 87% yield), MS: m/e=316.2 (M+H+).