Water → 1-[2-(Benzyloxy)-6-hydroxyphenyl]ethan-1-one

HRID 230869

反応式

HRID 230869 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[C:9](=[O:11])[CH3:10].C(=O)([O-])[O-].[K+].[K+].[CH2:18](Br)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.O>CC(C)=O>[CH2:18]([O:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[C:9](=[O:11])[CH3:10])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

6

反応物 4

HCID 962WaterHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 696872',6'-Dihydroxyacetophenone

生成物 1

HCID 27751871-[2-(Benzyloxy)-6-hydroxyphenyl]ethan-1-one

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a mixture of 2′,6′-dihydroxyacetophenone (4 g) and potassium carbonate (3.82 g) in acetone (40 mL) was added benzyl bromide (3.13 mL), and the mixture was stirred at room temperature overnight. The reaction mixture was poured into water, and the precipitated crystals were collected by filtration. The crystals were washed with water and n-hexane, and dried under reduced pressure to give the title compound (3.67 g).

後処理

  1. filtrationthe precipitated crystals were collected by filtration
  2. washThe crystals were washed with water and n-hexane
  3. customdried under reduced pressure

出典と根拠

ORDレコード
ord-ad510b46ab0447c5abe0f9bfcbc6058e
出典データセット
uspto-grants-2009_07
特許番号
US07566699B2

関連ノート

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