Hydrogen Bromide → HCID 20186414、化合物

反応式

C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:15][CH2:14][C:13]3[CH:12]=[N:11][NH:10][C:9]=3[C:7]=2[CH:8]=1.Br.C(=O)(O)[O-].[Na+]>>[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[S:15][CH2:14][C:13]3[CH:12]=[N:11][NH:10][C:9]=3[C:7]=2[CH:8]=1

参加物

反応物 3

HCID 260Hydrogen Bromide

HCID 516892Sodium Bicarbonate

HCID 20186429HCID 20186429、化合物

生成物 1

HCID 20186414HCID 20186414、化合物収率 74.9%

実験手順

A mixture of 8-methoxy-1,4-dihydro[1]benzothiopyrano[4,3-c]pyrazole (6.75 g) and 47% hydrobromic acid (70.2 ml) was refluxed for 3 hours with stirring and allowed to cool to room temperature. The resulting precipitate was collected by filtration and recrystallized from water to give the salt, which was treated with aqueous sodium bicarbonate to give 8-hydroxy-1,4dihydro[1]benzothiopyrano[4,3-c]pyrazole (4.73 g).