Hydrogen Bromide → 106487-34-7
反応式
C[O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:13]2[CH2:18][CH2:17][CH2:16][N:15]([CH2:19][CH2:20][CH3:21])[CH2:14]2)=[C:7]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8]2.[BrH:22]>>[BrH:22].[OH:2][C:3]1[CH:4]=[CH:5][C:6]([CH:13]2[CH2:18][CH2:17][CH2:16][N:15]([CH2:19][CH2:20][CH3:21])[CH2:14]2)=[C:7]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8]2参加物
3
実験手順
1.55 g of the product of Example 2 in 15 ml of 48% hydrobromic acid were refluxed for 2 hours with stirring under an inert atmosphere. After evaporating to dryness under reduced pressure, crystallizing the oil obtained from ethanol, filtering, washing with ether, drying, and purifying by crystallization from methanol, 1.31 g of 1,3-dihydro-7-hydroxy-4-(1-propyl-3-piperidinyl)-2H-indol-2-one hydrobromide melting at 210° C. were obtained.
後処理
- customAfter evaporating to dryness under reduced pressure
- customcrystallizing the oil
- customobtained from ethanol
- filtrationfiltering
- washwashing with ether
- customdrying
- custompurifying by crystallization from methanol