Ethyl formate → 2-Phenyl-2-[4-(4-pyridyl)-2-thiazolyl]acetaldehyde

HRID 2309796

反応式

HRID 2309796 の反応式
[CH2:1]([C:8]1[S:9][CH:10]=[C:11]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[N:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CN(C)CCN(C)C.C([Li])CCC.[CH:32](OCC)=[O:33]>O1CCCC1>[C:2]1([CH:1]([C:8]2[S:9][CH:10]=[C:11]([C:13]3[CH:14]=[CH:15][N:16]=[CH:17][CH:18]=3)[N:12]=2)[CH:32]=[O:33])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 8025Ethyl formateHCID 8037N,N,N',N'-TetramethylethylenediamineHCID 140969524-(2-Benzyl-1,3-thiazol-4-yl)pyridineHCID 178418339Butyllithium

生成物 1

HCID 140969562-Phenyl-2-[4-(4-pyridyl)-2-thiazolyl]acetaldehyde収率 39%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
-78 °C

実験手順

To a solution of 2-benzyl-4-(4-pyridyl)thiazole (4.00 g, 0.016 mol) and tetramethylethylenediamine (2.5 mL) in dry tetrahydrofuran (35 mL) at -78° C. under nitrogen atmosphere was added dropwise n-butyl lithium (1.6M in hexane, 11.4 mL). The resulting dark mixture was allowed to stir at -78° C. for 15 minutes, warmed to 0° C. for 2 hours, then cooled to -78° C. Ethyl formate (1.47 mL) was added dropwise and the mixture allowed to stir at -78° C. for 30 minutes then at 0° C. for one hour. The reaction mixture was quenched with methanol, concentrated, and chromatographed over silica gel. Recrystallization from hexane/ethyl acetate afforded 2-phenyl-2-[4-(4-pyridyl)-2-thiazolyl]acetaldehyde (1.76 g, 39%). mp. 163°-164° C.

後処理

  1. temperaturewarmed to 0° C. for 2 hours
  2. temperaturecooled to -78° C
  3. stirringto stir at -78° C. for 30 minutes
  4. waitat 0° C. for one hour
  5. customThe reaction mixture was quenched with methanol
  6. concentrationconcentrated
  7. customchromatographed over silica gel
  8. customRecrystallization from hexane/ethyl acetate

出典と根拠

ORDレコード
ord-25e6a893b6fb46ba928878729d627924
出典データセット
uspto-grants-1987_09
特許番号
US04697012

関連ノート

読み込み中…