Hydrochloric Acid → HCID 20184547、化合物

HRID 2309862ノート

反応式

HRID 2309862 の反応式
[CH3:1][N:2]([CH3:21])[C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[CH:6]=[CH:5][C:4]=1[C:12]1[NH:13][C:14]2[C:15]([N:20]=1)=[N:16][CH:17]=[CH:18][CH:19]=2.[ClH:22].[H][H]>CO.[Pd]>[ClH:22].[ClH:22].[CH3:1][N:2]([CH3:21])[C:3]1[CH:8]=[C:7]([NH2:9])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:13][C:14]2[C:15]([N:20]=1)=[N:16][CH:17]=[CH:18][CH:19]=2

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 132845112-(1H-Imidazo[4,5-b]pyridin-2-yl)-N,N-dimethyl-5-nitroanilineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 20184547HCID 20184547、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

An amount of 2.83 gm of 2-(2'-dimethylamino-4'-nitrophenyl)-imidazo[4,5-b]pyridine was hydrogenated in a mixture of 100 ml of methanol, 10 ml of concentrated methanolic hydrochloric acid, and 1 gm of palladium/charcoal for 4.5 hours at ambient temperature with hydrogen gas at 5 bar. The catalyst was then removed by filtration, the filtrate was concentrated by evaporation, and the residue was triturated with acetone to form crystals, filtered, and then washed with a mixture of ether and acetone.

後処理

  1. customThe catalyst was then removed by filtration
  2. concentrationthe filtrate was concentrated by evaporation
  3. customthe residue was triturated with acetone
  4. customto form crystals
  5. filtrationfiltered
  6. washwashed with a mixture of ether and acetone

出典と根拠

ORDレコード
ord-fa34572d4c314bc784e505ad42eb54b4
出典データセット
uspto-grants-1987_09
特許番号
US04696931

反応ノート

読み込み中…