Methanesulfonyl chloride → HCID 13284512、化合物

HRID 2309890ノート

反応式

HRID 2309890 の反応式
Cl.Cl.[CH3:3][N:4]([CH3:21])[C:5]1[CH:10]=[C:9]([NH2:11])[CH:8]=[CH:7][C:6]=1[C:12]1[NH:13][C:14]2[C:15]([N:20]=1)=[N:16][CH:17]=[CH:18][CH:19]=2.[CH3:22][S:23](Cl)(=[O:25])=[O:24]>N1C=CC=CC=1>[CH3:3][N:4]([CH3:21])[C:5]1[CH:10]=[C:9]([NH:11][S:23]([CH3:22])(=[O:25])=[O:24])[CH:8]=[CH:7][C:6]=1[C:12]1[NH:13][C:14]2[C:15]([N:20]=1)=[N:16][CH:17]=[CH:18][CH:19]=2

参加物

4

反応物 2

HCID 31297Methanesulfonyl chlorideHCID 20184547HCID 20184547、化合物

生成物 1

HCID 13284512HCID 13284512、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

An amount of 0.49 gm 2-(2'-dimethylamino-4'-aminophenyl)-imidazo[4,5-b]pyridine dihydrochloride was dissolved in 10 ml of pyridine, 0.38 gm of methanesulfonyl chloride were added dropwise, and the mixture was stirred for two days at ambient temperature. The reaction mixture was poured onto water, and the solution obtained was extracted with ethyl acetate. The ethyl acetate phases were washed with common salt solution and concentrated by evaporation. The residue was triturated with 2N acetic acid, subjected to filtration, and washed with water.

後処理

  1. additionThe reaction mixture was poured onto water
  2. customthe solution obtained
  3. extractionwas extracted with ethyl acetate
  4. washThe ethyl acetate phases were washed with common salt solution
  5. concentrationconcentrated by evaporation
  6. customThe residue was triturated with 2N acetic acid
  7. filtrationsubjected to filtration
  8. washwashed with water

出典と根拠

ORDレコード
ord-950efe23944e4a03a14e23086bc5c559
出典データセット
uspto-grants-1987_09
特許番号
US04696931

反応ノート

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