4-Hydroxybenzoic Acid → 4-(1-Methylheptyloxycarbonyl)phenol

HRID 231025

反応式

HRID 231025 の反応式
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.[CH3:11][C@@H:12](O)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].S(=O)(=O)(O)O>C1C=CC=CC=1>[CH3:11][CH:12]([O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([OH:1])=[CH:3][CH:4]=1)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

参加物

5

反応物 3

HCID 1354-Hydroxybenzoic AcidHCID 1118Sulfuric AcidHCID 80080(R)-2-Octanol

生成物 1

HCID 110103794-(1-Methylheptyloxycarbonyl)phenol収率 43%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

27.6 g of p-hydroxybenzoic acid and 39.0 g of (R)-2-octanol were refluxed for 10 hours in 300 ml of benzene in the presence of 0.5 ml of conc. sulfuric acid. Then, the reaction solution was cooled to the room temperature, and then concentrated and purified by column chromatography, to obtain 21.5 g of p-hydroxybenzoic acid 1-methylheptyl ester. (yield: 43%)

後処理

  1. concentrationconcentrated
  2. custompurified by column chromatography

出典と根拠

ORDレコード
ord-9a63337d10b54f90af339903302db2f4
出典データセット
uspto-grants-1989_07
特許番号
US04844835

関連ノート

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