Formaldehyde → Indole-2,3-dione, 1-(hydroxymethyl)-

HRID 231031ノート

反応式

HRID 231031 の反応式
[NH:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[C:2]1=[O:3].C=O.[O:14]1CCOC[CH2:15]1>O>[OH:14][CH2:15][N:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[C:2]1=[O:3]

参加物

5

反応物 3

HCID 712FormaldehydeHCID 7054IsatinHCID 312751,4-Dioxane

生成物 1

HCID 39834Indole-2,3-dione, 1-(hydroxymethyl)-収率 93%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

Isatin (25 g, 0.17 mol) and 30% formalin (30 ml, 0.3 mol) were added to a mixture of dioxane (10 ml) and water (20 ml) and the mixture was heated at 100° C. for 5 hours. The reaction mixture was cooled and crystals formed were filtered off. N-hydroxymethylisatin (28 g, yield 93%) was obtained. The melting point was 138° C. (decomposed).

後処理

  1. temperatureThe reaction mixture was cooled
  2. customcrystals formed
  3. filtrationwere filtered off

出典と根拠

ORDレコード
ord-e300c7d5fad146689fff82c67bdf00df
出典データセット
uspto-grants-1989_07
特許番号
US04845020

反応ノート

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