Thionyl Chloride → N-Chloromethylisatin

HRID 231032ノート

反応式

HRID 231032 の反応式
O[CH2:2][N:3]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:6](=[O:7])[C:4]1=[O:5].S(Cl)([Cl:16])=O>>[Cl:16][CH2:2][N:3]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:6](=[O:7])[C:4]1=[O:5]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 39834Indole-2,3-dione, 1-(hydroxymethyl)-

生成物 1

HCID 12207287N-Chloromethylisatin

実験手順

N-Hydroxymethylisatin (10 g, 0.056 mol) was added to thionyl chloride (100 ml) and the mixture was heated under reflux for 2 hours. N-Chloromethylisatin (about 11 g) was obtained by distilling the remaining thionyl chloride under reduced pressure. The melting point was 121° to 123° C.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 2 hours

出典と根拠

ORDレコード
ord-5334c4e95c64423ba49a5bf357cb5e8e
出典データセット
uspto-grants-1989_07
特許番号
US04845020

反応ノート

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