2-(Bis(methylsulfanyl)methylidene)propanedinitrile → 5-Amino-4-cyano-3-methylthio-1-(3-trifluoromethylbenzyl)-pyrazole

HRID 231038

反応式

HRID 231038 の反応式
[C:1]([C:3]([C:9]#[N:10])=[C:4]([S:7][CH3:8])SC)#[N:2].[F:11][C:12]([F:23])([F:22])[C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][CH:21]=1)[CH2:16][NH:17][NH2:18]>C(O)C>[F:11][C:12]([F:22])([F:23])[C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][CH:21]=1)[CH2:16][N:17]1[C:1]([NH2:2])=[C:3]([C:9]#[N:10])[C:4]([S:7][CH3:8])=[N:18]1

参加物

4

反応物 2

HCID 992292-(Bis(methylsulfanyl)methylidene)propanedinitrileHCID 599698((3-(Trifluoromethyl)phenyl)methyl)hydrazine

生成物 1

HCID 140710225-Amino-4-cyano-3-methylthio-1-(3-trifluoromethylbenzyl)-pyrazole収率 80%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
20 °C

実験手順

8.5 g of 1,1-dicyano-2,2-bis-(methylmercapto)-ethylene and 9.5 g of 3-trifluoromethyl-benzylhydrazine are mixed in 100 ml of ethanol. The mixture is stirred for 15 hours at 20° C. and the solvent is evaporated in a rotary evaporator. The residue is triturated in petroleum ether. 12.4 g (80% of theory) of 1-(3-trifluoromethylbenzyl)-3-methylmercapto-4-cyano-5-amino-pyrazol of melting point 142° C. are obtained.

後処理

  1. customthe solvent is evaporated in a rotary evaporator
  2. customThe residue is triturated in petroleum ether

出典と根拠

ORDレコード
ord-2bb6033b34274278a7fe1a46953b216c
出典データセット
uspto-grants-1989_07
特許番号
US04845089

関連ノート

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