Acetic Anhydride → 1-Acetoxymethyl-2-(4-methoxy-2-picolylmercapto)-1H-thieno[3,4-d]imidazole

反応式

[OH:1][CH2:2][N:3]1[C:7]2=[CH:8][S:9][CH:10]=[C:6]2[N:5]=[C:4]1[S:11][CH2:12][C:13]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][N:14]=1.[C:21](OC(=O)C)(=[O:23])[CH3:22]>N1C=CC=CC=1.CN(C)C1C=CN=CC=1>[C:21]([O:1][CH2:2][N:3]1[C:7]2=[CH:8][S:9][CH:10]=[C:6]2[N:5]=[C:4]1[S:11][CH2:12][C:13]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][N:14]=1)(=[O:23])[CH3:22]

参加物

実験手順

1.3 g (4.2 mmol) of the title compound from Example 28 were dissolved in 25 ml of anhydrous pyridine, and 50 mg of 4-dimethylaminopyridine were added. Under a nitrogen atmosphere and while stirring, 6.3 ml acetic anhydride were added dropwise, and the mixture was stirred at room temperature for one hour. It was then poured onto ice water, extracted with methylene chloride, and the organic phase was dried over MgSO4 and concentrated in vacuo. The crystalline solid was recrystallized from ethanol. Melting point 111°-113° C.