反応式
ClC1C=CC=[C:4]([C:8](OO)=[O:9])C=1.C([C@H:15]1[NH:18][C:17](=[O:19])[C@H:16]1[C@H:20]([O:22][Si:23]([C:26]([CH3:29])([CH3:28])[CH3:27])([CH3:25])[CH3:24])[CH3:21])(=O)C.C(=O)([O-])[OH:31].[Na+].CSC>C(OCC)(=O)C>[C:8]([O:19][C@H:17]1[NH:18][C:15](=[O:31])[C@H:16]1[C@H:20]([O:22][Si:23]([C:26]([CH3:27])([CH3:28])[CH3:29])([CH3:24])[CH3:25])[CH3:21])(=[O:9])[CH3:4]参加物
6
反応物 4
生成物 1
試薬・触媒・溶媒 1
実験手順
m-Chloroperbenzoic acid (0.5 g) is added to a solution of the object compound of Example 22 (0.08g) in ethyl acetate (8 ml), and the mixture is stirred at room temperature for 3 days and then poured into a mixture of ethyl acetate (50 ml), aqueous sodium hydrogen carbonate (20 ml) and dimethyl sulfide (0.4 ml). The mixture is stirred at room temperature for 30 minutes. The organic layer is separated, washed with brine, dried over magnesium sulfate and concentrated under reduced pressure. The residue is subjected to silica gel column chromatography (eluent: 15% ethyl acetate-85% hexane) to give 0.045 g of (3S,4R)-4-acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone.
後処理
- stirringThe mixture is stirred at room temperature for 30 minutes
- customThe organic layer is separated
- washwashed with brine
- dry with materialdried over magnesium sulfate
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-295a58d7d27a4aad9f5d6f9e24a55e1f
- 出典データセット
- uspto-grants-1989_07
- 特許番号
- US04845210
関連ノート
読み込み中…