2-Chloro-4-fluoro-5-nitrotoluene → 4-Chloro-2-fluoro-5-methylaniline

HRID 231407

反応式

HRID 231407 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([N+:9]([O-])=O)=[CH:4][C:3]=1[CH3:12].[H][H]>C(O)(=O)C.[Pt]>[Cl:1][C:2]1[C:3]([CH3:12])=[CH:4][C:5]([NH2:9])=[C:6]([F:8])[CH:7]=1

参加物

5

反応物 2

HCID 101039792-Chloro-4-fluoro-5-nitrotolueneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 141574954-Chloro-2-fluoro-5-methylaniline

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 176Acetic Acid溶媒

実験手順

A solution of 2-chloro-4-fluoro-5-nitrotoluene (30.0 g, 0.158 mole) in glacial acetic acid (150 ml) was added to a 250 ml Parr bottle which contained platinum IV oxide (0.4 g). The Parr bottle was placed on a Parr hydrogenation apparatus and charged with hydrogen. The reaction mixture was allowed to shake until hydrogen absorption ceased. The catalyst was removed by vacuum filtration. The filtrate containing 4-chloro-2-fluoro-5-methylaniline was used in the following step. This reaction was repeated several times.

後処理

  1. customto shake until hydrogen absorption
  2. customThe catalyst was removed by vacuum filtration
  3. additionThe filtrate containing 4-chloro-2-fluoro-5-methylaniline

出典と根拠

ORDレコード
ord-9b0c3425db194681af283128da57f87f
出典データセット
uspto-grants-1989_07
特許番号
US04846875

関連ノート

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