化工社化工社 化学情報印刷レポート · 研究参考用
3'-(Trifluoromethyl)acetophenone → (E)-3-(dimethylamino)-1-[3-(trifluoromethyl)phenyl]-2-buten-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3'-(Trifluoromethyl)acetophenone | HCID 67682 | — |
| 反応物 | 1,1-Dimethoxyethyl(dimethyl)amine | HCID 87835 | — |
| 生成物 | (E)-3-(dimethylamino)-1-[3-(trifluoromethyl)phenyl]-2-buten-1-one | HCID 53396592 | — |
反応手順
A mixture of 20.0 g of 3-trifluoromethylacetophenone and 20 ml of N,N-dimethylacetamide dimethyl acetal was stirred and heated at reflux for 3 hours. The mixture was evaporated in vacuo to give a red solid. The solid was triturated with n-hexane and filtered. The solid was washed with n-hexane and dried to give 18.0 g of 3-(dimethylamino)-1-[3-(trifluoromethyl)phenyl]-2-buten-1-one as red crystals, mp 71°-73° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04847256 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-3cb7a6da37ae47bdaaedf2742a85337d |
| 出典メモ | uspto-grants-1989_07 |