反应详情

A mixture of 20.0 g of 3-trifluoromethylacetophenone and 20 ml of N,N-dimethylacetamide dimethyl acetal was stirred and heated at reflux for 3 hours. The mixture was evaporated in vacuo to give a red solid. The solid was triturated with n-hexane and filtered. The solid was washed with n-hexane and dried to give 18.0 g of 3-(dimethylamino)-1-[3-(trifluoromethyl)phenyl]-2-buten-1-one as red crystals, mp 71°-73° C.

1. temperatureheated
2. temperatureat reflux for 3 hours
3. customThe mixture was evaporated in vacuo
4. customto give a red solid
5. customThe solid was triturated with n-hexane
6. filtrationfiltered
7. washThe solid was washed with n-hexane
8. customdried