Methyl 6-nitro-1H-indole-2-carboxylate → Methyl 6-amino-1H-indole-2-carboxylate

HRID 23153ノート

反応式

HRID 23153 の反応式
[CH3:1][O:2][C:3]([C:5]1[NH:6][C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[C:9]([N+:14]([O-])=O)[CH:8]=2)=[O:4]>CO.C(OC(=O)C)C.[Pd]>[CH3:1][O:2][C:3]([C:5]1[NH:6][C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[C:9]([NH2:14])[CH:8]=2)=[O:4]

参加物

4

反応物 1

HCID 11816863Methyl 6-nitro-1H-indole-2-carboxylate

生成物 1

HCID 22060206Methyl 6-amino-1H-indole-2-carboxylate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 21584119Ethylacetate methanol溶媒

実験手順

To a solution of 6-Nitro-1H-indole-2-carboxylic acid methyl ester (108) 200 mg (0.91 mmole) in a mixture of methanol/ethylacetate 1:1 10% Pd/C (40 mg) was added. The flask was rinsed 3 times with hydrogen and filled with hydrogen at 30 to 35 psi. The suspension was stirred vigorously at room temperature for 30 minutes. The catalyst was filtered off, the filtrate was evaporated in vacuo to dryness. The resulted 6-amino-1H-indole-2-carboxylic acid methyl ester gave a single spot on TLC (Silica, toluene-ethylacetate 7:3, Rf:0.31) and was used for the next step without purification

後処理

  1. additionwas added
  2. washThe flask was rinsed 3 times with hydrogen
  3. additionfilled with hydrogen at 30 to 35 psi
  4. filtrationThe catalyst was filtered off
  5. customthe filtrate was evaporated in vacuo to dryness

出典と根拠

ORDレコード
ord-cdd6a8e0b30745f3a6723f492fb8731a
出典データセット
uspto-grants-2005_02
特許番号
US06849713B2

反応ノート

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