p-Chlorophenacyl bromide → 8-Bromo-6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine

HRID 231532

反応式

HRID 231532 の反応式
[NH2:1][C:2]1[C:7]([Br:8])=[CH:6][C:5]([Cl:9])=[CH:4][N:3]=1.Br[CH2:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=1)=O.C(=O)([O-])O.[Na+]>C(O)C>[Br:8][C:7]1[C:2]2[N:3]([CH:11]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)[N:1]=2)[CH:4]=[C:5]([Cl:9])[CH:6]=1

参加物

5

反応物 3

HCID 68303p-Chlorophenacyl bromideHCID 516892Sodium BicarbonateHCID 27639713-Bromo-5-chloropyridin-2-amine

生成物 1

HCID 142349178-Bromo-6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

17 g (82 mmol) of 2-amino-3-bromo-5-chloropyridine dissolved in 150 ml of ethanol are reacted with 29 g of 2-bromo-1-(4-chlorophenyl)-1-ethanone and 14 g of sodium hydrogen carbonate. The mixture is brought to the refluxing temperature for 6 h and cooled. The precipitate is filtered off and rinsed with CH2Cl2, and the filtrate is concentrated under reduced pressure. After recrystallization of the evaporation residue in ethyl acetate, the compound melts at 178° C.

後処理

  1. temperaturecooled
  2. filtrationThe precipitate is filtered off
  3. washrinsed with CH2Cl2
  4. concentrationthe filtrate is concentrated under reduced pressure
  5. customAfter recrystallization of the evaporation residue in ethyl acetate

出典と根拠

ORDレコード
ord-8a2f27f02afd4b7b85817dfa22b20cfb
出典データセット
uspto-grants-1989_07
特許番号
US04847263

関連ノート

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