Water → 2-Amino-4-phenylthiazole

HRID 231546

反応式

HRID 231546 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[NH2:11][C:12]([NH2:14])=[S:13].O>CO>[NH2:14][C:12]1[S:13][CH:2]=[C:3]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:11]=1

参加物

5

反応物 3

HCID 962WaterHCID 6259Phenacyl bromideHCID 2723790Thiourea

生成物 1

HCID 403022-Amino-4-phenylthiazole収率 85.15%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 19.9 g (0.10 mol) of α-bromo-acetophenone and 11.4 g (0.15 mol) of thiourea in 75 ml of methanol is refluxed for 2 h. It is evaporated to dryness under reduced pressure and the evaporation residue is taken up with water. The resulting solution, heated to the reflux temperature, is treated with CXA charcoal and then rendered alkaline with aqueous ammonia. The precipitate formed is isolated by filtration and purified by recrystallization from isopropanol, with CXA charcoal treatment. to give 15 g (yield: 85.15%) of the expected product in the form of water-insoluble white needles. M.p. (inst.)=150° C.

後処理

  1. customIt is evaporated to dryness under reduced pressure
  2. temperatureThe resulting solution, heated to the reflux temperature
  3. additionis treated with CXA charcoal
  4. customThe precipitate formed
  5. customis isolated by filtration
  6. custompurified by recrystallization from isopropanol, with CXA charcoal treatment

出典と根拠

ORDレコード
ord-c7e2722c24ed4f17a5955e331ecbdc30
出典データセット
uspto-grants-1989_07
特許番号
US04847274

関連ノート

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